The research was on the thrust to examine the influence of advertisement on students’ choice of toothpaste among students with a focus of University of Lagos students. The research was anchored on Uses and Gratifications Theory and Persuasion Theory. The research used Survey research method with the questionnaire as data collection instrument. The data collected was analyzed using Descriptive Statistics (Frequency Statistics) method. Finding shows that students prefer Oral B, Pestisodent and Toothpaste. It was recommended that advertisement should not deceive people in order to help students make appropriate choice.