The research examines perception of people on media reportage of monkey pox outbreak in Lagos. It is established that radio, television and other mass media are essential tools for promoting awareness on various matters including the outbreak of Monkey pox. The study was anchored on Agenda Setting Theory and Perception Theory. Survey research method was used coupled with questionnaire that was used to elicit responses from the respondents that were drawn using sampling by convenience in which 150 respondents were picked within Alimosho local government. The data collected were analyzed using frequency and percentage. Majority of the respondents admitted that radio (37%) and television (30%) are most effective during the outbreak of monkey pox as it communicate to even the illiterate. It is recommended that media should development proactive and responsive programmes to prevent, create awareness and educate people before and during the outbreak of any disease in order for people to prepare ahead and prevent such phenomena.